Paris St-Germain boss Thomas Tuchel has confirmed Edinson Cavani will not face Manchester United due to a hip injury.
Fellow forward Neymar is already ruled out of Tuesday’s first leg and the return game on 6 March through injury.
Tuchel says Cavani’s absence at Old Trafford is an additional blow.
He said: “Would Man Utd miss Pogba or Rashford? Of course. Neymar is one of our best players and one of the best players in Europe. We will miss him a lot. And now Cavani is out.”
The 31-year-old injured a tendon in his hip after scoring a penalty in Saturday’s 1-0 victory over Bordeaux.
Neymar is out for 10 weeks with a broken metatarsal suffered in a 2-0 French Cup victory over Strasbourg on 23 January.